REVIEW ARTICLE


A Narrative Review: Exercise Induces Adipose Browning by Altering the Gut Microbiome Profile



Dini Suryani1, 2, Vita Murniati Tarawan3, Imam Megantara4, Ronny Lesmana3, 5, Nova Sylviana3, 5, Hanna Goenawan3, 5, *
1 Biomedical Science Master Program, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia
2 Department of Physiology, Faculty of Medicine, Mataram University, Mataram, Indonesia
3 Physiology Division, Department of Biomedical Science, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia
4 Microbiology Division, Department of Biomedical Science, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia
5 Physiology Molecular, Division of Biological Activity, Central Laboratory, Padjajaran University, Bandung, Indonesia


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Creative Commons License
© 2022 Suryani et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Physiology Division, Department of Biomedical Science, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; E-mail: hanna@unpad.ac.id


Abstract

Obesity is a condition that is highly associated with chronic diseases. The number of obese individuals is increasing on a global scale every year. Energy intake that is imbalanced with energy expenditure causes the accumulation of excess fat. Regular exercise is part of a lifestyle that can reduce the risk of obesity by inducing adipose browning. One of the mechanisms of exercise in inducing browning is by modifying the gut microbiome profile. This profile may promote adipose browning by maintaining the integrity of the intestinal barrier, glucose homeostasis, regulating energy absorption, and appetite-regulating hormones.

Keywords: Exercise, Gut, Microbiome, Browning, Beiging, Adipose.